ReviewInternational journal of molecular sciences2026
The Application of Injectable Hydrogels in Myocardial Infarction Repair: Material Design, Biological Functions and Clinical Translation.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
Abstract
Myocardial infarction remains a major clinical challenge because ischemic injury triggers inflammation, oxidative stress, cardiomyocyte loss, impaired vascularization, and adverse ventricular remodeling. Injectable hydrogels offer a minimally invasive and versatile strategy for post-infarction cardiac repair by providing structural support, localized bioactive delivery, and dynamic modulation of the injured myocardial microenvironment. This review highlights pathology-informed design principles for injectable hydrogels, including shear-thinning injectability, in situ gelation, tissue adhesion, modulus matching, fatigue resistance, biodegradability, and controlled bioactivity. We further discuss hydrogel-based strategies for immunomodulation, angiogenesis, fibrosis attenuation, extracellular matrix remodeling, and myocardial regeneration. Finally, translational progress and key challenges involving biosafety, scalable manufacturing, standardization and long-term efficacy are examined. This review provides a concise framework for developing next-generation injectable hydrogels for myocardial infarction repair and clinical translation.
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