Evidence map›Paper›PMID 42511788›Full record

ReviewInternational journal of molecular sciences2026

Auger-Emitting Radionuclides in Radiopharmaceutical Research: Decay-Associated Processes, Vector-Dependent Localization, and Translational Perspectives.

Klaus Schomäcker, Ferdinand Sudbrock, Melanie Freifrau von Brandenstein, Baki Akgül, Martin Hufbauer, Thomas Fischer, Sabri E M Sahnoun, Felix Dietlein, Philipp Krapf, Markus Dietlein and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Klaus SchomäckerDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0003-2636-0058
Ferdinand SudbrockDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Melanie Freifrau von BrandensteinDepartment of Urology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Baki AkgülInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, Germany.ORCID 0000-0002-6564-9412
Martin HufbauerInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, Germany.ORCID 0000-0003-4106-0520
Thomas FischerDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0001-6118-5182
Sabri E M SahnounDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Felix DietleinComputational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6651-7155
Philipp KrapfDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Markus DietleinDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0003-0992-6099
Alexander DrzezgaDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Auger-electron-emitting radionuclides offer a distinctive route toward molecular-scale radiotherapy because their biological effects depend primarily on the nanoscale location of the decay event rather than on long-range tissue penetration. This review examines Auger-emitting radionuclides from a radiopharmaceutical perspective, integrating decay-associated physicochemical processes, cellular dosimetry, subcellular targeting, and translational relevance. We first discuss the physical determinants of Auger radiotoxicity, including Auger and Coster-Kronig electrons, internal-conversion electrons, local ionization density, and possible molecular consequences of highly localized Auger cascades. Cellular S values are used to illustrate how the same radionuclide can produce markedly different absorbed doses depending on whether activity is localized in the nucleus, cytoplasm, cell membrane, or neighboring cells. Iodine-125 incorporated into DNA as [

Indexed as

RadioisotopesRadiopharmaceuticalsAnimalsElectronsHumansIodine RadioisotopesIodine RadioisotopesRadioisotopesRadiopharmaceuticalsAuger electronscellular dosimetryCoster–Kronig electronsCoulomb explosionDNA damageinternal conversion electronsradiopharmaceutical therapysubcellular localizationtechnetium-99mterbium-161

Identifiers

PMID42511788
PMCPMC13411172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.