DcR3 Suppresses Lipopolysaccharide-Induced Aggresome-like Structures in Macrophages via Inhibition of Reactive Oxygen Species and p38 MAPK.

Chun-Hung Lee, Duen-Yi Huang, Shie-Liang Hsieh, Yuan-Shen Chen, Wan-Wan Lin

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chun-Hung LeeDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Duen-Yi HuangDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Shie-Liang HsiehInstitute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.

Yuan-Shen ChenDepartment of Neurosurgery, National Taiwan University Hospital Yunlin Branch, Douliu 64041, Taiwan.

Wan-Wan LinDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-3207-734X

Funding

National Science and Technology Council NSTC 113-2314-B-567-001, NSTC 113-2320-B-002 -010 -MY3National Taiwan University Hospital NTUHYL 110.S021

6 · The paper itself

Abstract

Decoy receptor 3 (DcR3) is a pleiotropic soluble factor that modulates cellular functions through both decoy and non-decoy mechanisms. DcR3 has been reported to exert anti-apoptotic and anti-inflammatory effects in humans, particularly in cancers and inflammatory diseases. In the present study, we investigated the role of DcR3 in TLR4-mediated innate immune responses in macrophages. Because the

Indexed as

LipopolysaccharidesMacrophagesp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesReceptors, Tumor Necrosis Factor, Member 6bAnimalsAutophagyCyclooxygenase 2Interleukin-1betaMacrolidesMiceUbiquitinationCyclooxygenase 2Interleukin-1betaLipopolysaccharidesMacrolidesp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesReceptors, Tumor Necrosis Factor, Member 6bALISautophagybone marrow-derived macrophagesDcR3inflammationlipopolysaccharideubiquitination

Identifiers

PMID42511776

DOI10.3390/ijms27146433

PMCPMC13410495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.