Spiramide and Hydroquinidine Inhibit Proliferation and Migration While Promoting Apoptosis and Oxidative Stress in Neuroblastoma Cells.

Evren Gümüş, İlknur Keskin, Ezgi Yıldırım, Servet Kavak, Turan Demircan

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evren GümüşMedical Genetics Department, School of Medicine, Muğla Sıtkı Koçman University, Muğla 48000, Turkey.ORCID 0000-0001-9932-0730

İlknur KeskinHistology and Embryology Department, School of Medicine, İstanbul Medipol University, İstanbul 34214, Turkey.

Ezgi YıldırımMolecular Biology and Genetics, Institute of Natural Sciences, Muğla Sıtkı Koçman University, Muğla 48000, Turkey.ORCID 0009-0009-3335-364X

Servet KavakBiophysics Department, School of Medicine, İzmir Bakırçay University, İzmir 35665, Turkey.

Turan DemircanMedical Biology Department, School of Medicine, İzmir Bakırçay University, İzmir 35665, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma is an aggressive pediatric malignancy with limited therapeutic options for high-risk disease, underscoring the need for alternative treatment strategies. Drug repurposing offers a promising approach to accelerate the identification of effective anti-cancer agents. In this study, we investigated the anti-carcinogenic effects of hydroquinidine, a class IA antiarrhythmic ion channel blocker, and spiramide, a dopamine D

Indexed as

Antineoplastic AgentsApoptosisCell MovementCell ProliferationNeuroblastomaOxidative StressQuinidineCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticHumansAntineoplastic AgentsQuinidineAMI-193apoptosiscell proliferationdrug repurposinghydroquinidineneuroblastomaReactive Oxygen Species (ROS)SH-SY5Y

Identifiers

PMID42511714

DOI10.3390/ijms27146367

PMCPMC13409944

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.