ArticleInternational journal of molecular sciences2026
Lithium Chloride-Induced Nuclear Envelope Remodeling in 3D Endometrial Cancer Spheroids.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Selective remodeling of nuclear architecture under pharmacological stress remains incompletely characterized in three-dimensional cancer models, particularly at the ultrastructural level. Lithium chloride (LiCl) is widely used as a cellular stressor capable of altering membrane organization, proliferation, and organelle dynamics; however, its effects on nucleus-associated structural remodeling in three-dimensional tumor systems remain unclear. In the present study, Ishikawa endometrial carcinoma spheroids were exposed to LiCl (10 or 50 mM) for up to 96 h, and cellular responses were evaluated using cell cycle analysis, 5-bromo-2'-deoxyuridine (BrdU) incorporation, viability assays, and transmission electron microscopy. LiCl exposure was associated with sustained accumulation of cells in the G
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