Evidence map›Paper›PMID 42511690›Full record

SynthesisInternational journal of molecular sciences2026

Effects of Treatment with L-Thyroxine on Chronic Urticaria in Subjects with Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.

Monia Bordoni, Alessandro Ciarloni, Nairus Aboud, Elisabetta Sidori, Francesca Silvetti, Augusto Taccaliti, Alberto Vassallo, Marilina Romeo, Gianmaria Salvio, Giancarlo Balercia

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monia BordoniEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Alessandro CiarloniEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0009-0000-4945-6437
Nairus AboudEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Elisabetta SidoriEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Francesca SilvettiEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0001-5418-4819
Augusto TaccalitiEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Alberto VassalloDepartment of Diabetology and Endocrinology, Ospedale Maggiore di Lodi, 26900 Lodi, Italy.ORCID 0009-0004-8633-7700
Marilina RomeoEndocrinology and Diabetes Unit, Humanitas Gavazzeni, 24125 Bergamo, Italy.
Gianmaria SalvioEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0001-9290-5699
Giancarlo BalerciaEndocrinology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0003-1286-1521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic urticaria (CU) is a condition characterized by recurrent wheals/angioedema lasting longer than 6 weeks. It is treated in a stepwise manner, starting with antihistamines and escalating to more advanced therapies, if needed. It is frequently associated with autoimmune thyroiditis (AT), and thyroid autoantibodies and thyroid-stimulating hormone (TSH) may contribute to the severity of symptoms, though the exact pathogenesis remains unclear. We performed a systematic search on Scopus and Pubmed databases, finding nine studies published between 1989 and 2018. Five studies were therefore included in our meta-analysis, and we found that the treatment with L-thyroxine (LT4) is associated with a significant improvement in CU symptoms (sMD -2.31, 95% CI -2.98 to -1.64;

Indexed as

Chronic UrticariaThyroiditis, AutoimmuneThyroxineHumansTreatment OutcomeThyroxineautoimmunitychronic urticariaHashimoto’s thyroiditishypothyroidismL-T4thyroid peroxidase

Identifiers

PMID42511690
PMCPMC13410477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.