ArticleInternational journal of molecular sciences2026
Conduction Block in the Human Ischemic Myocardium: Insights from a 1D Electromechanical Model.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute myocardial ischemia, caused by a sudden reduction in coronary blood flow, initiates metabolic disturbances that lead to severe pathophysiological consequences. These include electrophysiological alterations, such as changes in action potential morphology and impaired electrotonic coupling between cardiomyocytes, and mechanical dysfunction, characterized by reduced contractile force and subsequent mechanical discoordination across the ventricular wall. This study employs multi-scale mathematical modeling to investigate the effects of acute ischemia on the electromechanical activity of a single human cardiomyocyte and a one-dimensional myocardial tissue. We identify the conditions for conduction block initiation and the parameters governing conduction restoration in ischemic tissue, and analyze the underlying mechanisms. Our simulations demonstrate that conduction slowing in the one-dimensional strand under ischemia directly results from the hyperkalemia-induced reduction in the fast sodium current (
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