Evidence map›Paper›PMID 42511631›Full record

ArticleInternational journal of molecular sciences2026

Mitochondrial Abundant Heat Soluble (MAHS) Protein Expression Modulates Metabolic Dynamics in Human Adipose-Derived Stem Cells.

Jordan L Rolsma, Julieanna Li, Ruthia Soh, Connor Nieh, Bryce Yeh, William Darch, Nicole Zur Nieden, Joshua T Morgan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan L RolsmaDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.
Julieanna LiDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.
Ruthia SohDepartment of Molecular, Cell & Systems Biology, University of California, Riverside, CA 92521, USA.ORCID 0000-0002-6339-9130
Connor NiehDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.
Bryce YehDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.
William DarchDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.
Nicole Zur NiedenDepartment of Molecular, Cell & Systems Biology, University of California, Riverside, CA 92521, USA.ORCID 0000-0003-4063-5070
Joshua T MorganDepartment of Bioengineering, University of California, Riverside, CA 92521, USA.ORCID 0000-0001-8033-0285

Funding

microRNA tuning of neural crest osteogenesisR01DE025330 · NIDCR · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZUR NIEDEN, NICOLE ISOLDE · 2016 to 2020
$1.9M
next-generation sequencing approaches to identify genotype-phenotype relationships during miRNA tuning of neural crest osteogenesisK18DE032513 · NIDCR · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZUR NIEDEN, NICOLE ISOLDE · 2023 to 2023
$127k
American Heart Association 19IPLOI34760636California Institute for Regenerative Medicine EDUC4-12752California Space Grant Consortium n/aNIDCR NIH HHS K18 DE032513NIDCR NIH HHS K18DE032513NIDCR NIH HHS R01 DE025330NIDCR NIH HHS R01DE025330U.S. National Science Foundation 2021307418U.S. National Science Foundation CAREER 2046093
6 · The paper itself

Abstract

Adipose-derived stem cells (ASCs) possess substantial regenerative potential, with lineage fate tightly coupled to metabolic dynamics. In prior work, we found that expression of the tardigrade-derived protein Mitochondrial Abundant Heat Soluble (MAHS) increased stress tolerance and promoted ASC osteogenic differentiation over adipogenic differentiation, although the mechanism remained unclear. Here, we leverage transcriptomic and functional assays to investigate how MAHS expression influences ASC metabolism. Transcriptomic profiling revealed incomplete adipogenic activation alongside upregulation of ossification-associated genes (e.g.,

Indexed as

Adipose TissueMitochondriaMitochondrial ProteinsStem CellsAdipogenesisCell DifferentiationCells, CulturedCyclic AMPHumansOsteogenesisSignal TransductionCyclic AMPMitochondrial Proteinsmitochondriamitochondrial heat-solubletardigrade

Identifiers

PMID42511631
PMCPMC13412036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.