Evidence map›Paper›PMID 42511629›Full record

ArticleInternational journal of molecular sciences2026

Absence of Thioredoxin Domain Containing 5 Improves Glucose Tolerance and Insulin Sensitivity in Male Mice.

Javier Sánchez-Marco, Cristina Barranquero, Roberto Martínez-Beamonte, Joaquín C Surra, Seyed Hesamoddin Bidooki, Luis V Herrera-Marcos, María-Jesús Rodríguez-Yoldi, María A Navarro, Marta Lopez-Yus, Jose M Arbonés-Mainar and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Javier Sánchez-MarcoDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-9023-741X
Cristina BarranqueroInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain.
Roberto Martínez-BeamonteInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-8100-5596
Joaquín C SurraInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-5841-0462
Seyed Hesamoddin BidookiDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-5612-5000
Luis V Herrera-MarcosInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-4665-9674
María-Jesús Rodríguez-YoldiInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-3595-7668
María A NavarroDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-0108-1004
Marta Lopez-YusInstituto de Investigación Sanitaria de Aragón, E-50009 Zaragoza, Spain.
Jose M Arbonés-MainarCIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, E-28029 Madrid, Spain.ORCID 0000-0002-8982-3737
Jesús OsadaDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, E-50013 Zaragoza, Spain.ORCID 0000-0002-8251-8457

Funding

Centro de Investigación Biomédica en Red CIBEROBN, CB06/03/1012European Union NextGenerationEU PRTR-C17.I1Gobierno de Aragón B16_23RMinisterio de Ciencia e Innovación PID2022-136414OB-I00SUDOE Manpower, S1/1.1/E0116
6 · The paper itself

Abstract

Thioredoxin domain-containing protein 5 (TXNDC5) plays a role in diseases related to oxidative stress, energy metabolism, and cellular inflammation. This protein has also been associated with diabetes and insulin folding. To gain insight into these relationships, glucose metabolism was characterized using

Indexed as

GlucoseInsulin ResistanceThioredoxinsAnimalsBlood GlucoseFatty Acids, NonesterifiedGluconeogenesisGlucose Tolerance TestInsulinLiverMaleMiceMice, Inbred C57BLMice, KnockoutBlood GlucoseFatty Acids, NonesterifiedGlucoseInsulinThioredoxinsG6pcglucoseglycemiaIgfbp1insulininsulin resistanceIrs2liverNEFAthioredoxin domain containing 5TXNDC5Txndc5-deficient mice

Identifiers

PMID42511629
PMCPMC13410217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.