ArticleInternational journal of molecular sciences2026
Nucleus Accumbens Hyperactivity and mPFC-NAc Circuit Dysfunction Promote Self-Injurious Behavior in Rats.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Self-injurious behavior (SIB) is a devastating and potentially life-threatening action with high prevalence in adolescents and patients with neuropsychiatric disorders. Accumulating evidence indicates that disruptions in multiple cellular and circuit mechanisms underlie vulnerability to SIB. We used an inducible SIB rat model to study synaptic modification during SIB. At 0.5 and 1 h after bilateral injection of muscimol (1.0 μg/side) into the rat endopeduncular nucleus (EP, a rodent homolog of the internal globus pallidus (GPi)), which induced SIB in rats, expression of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) and the phosphorylation of GluA1 at Ser831 and Ser845 were tested in the lateral habenula (LHb), ventral tegmental area (VTA), nucleus accumbens (NAc), amygdala, and medial prefrontal cortex (mPFC) of the rat brain. We also tested if modulation of NAc activity with a GABA
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