ArticleInternational journal of molecular sciences2026
Study of the Cytotoxic Effects of Au@Rh Core-Shell Metal Particles on the Osteosarcoma Cell Line HOS and the hFOB Osteoblast Cell Line.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteosarcoma, the most common primary malignant bone tumor in adolescents, faces treatment challenges due to metastasis and chemoresistance. This study developed a novel Au@Rh core-shell nanoparticle system functionalized with indocyanine green (ICG) to overcome hypoxia-limited photodynamic therapy (PDT). Au@Rh nanoparticles were synthesized via wet chemistry and characterized by UV-Vis spectroscopy, TEM, and cyclic voltammetry (CV). The system exhibited a core-shell morphology, well-defined crystalline planes, photothermal conversion and electrocatalytic activity. The Au@Rh nanoparticles (109 nm total size, 90 nm Au core, and 15 nm Rh shell) demonstrated dual functionality: the gold core provided photothermal conversion (a 7 °C temperature increase under NIR irradiation), while the rhodium shell exhibited pH-independent electrocatalytic activity for H
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