Evidence map›Paper›PMID 42511585›Full record

ArticleInternational journal of molecular sciences2026

Hierarchical Contrastive Learning for Protein-Protein Interaction Prediction Across Organisms.

Shiyi Liu, Buwen Liang, Yuetong Fang, Zixuan Jiang, Renjing Xu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Protein Language Models are Accidental Taxonomists.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shiyi LiuFunction Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, China.
Buwen LiangCollege of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China.
Yuetong FangFunction Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, China.ORCID 0000-0003-0228-9082
Zixuan JiangFunction Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, China.ORCID 0000-0001-5174-8244
Renjing XuFunction Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With advances in biomedical technologies and the continued expansion of experimental resources, biological data are growing rapidly in both scale and complexity. Contrastive learning provides an effective framework for integrating heterogeneous biological information. However, many protein-protein interaction (PPI) prediction methods still represent protein sequences and annotations as flat features and do not explicitly model hierarchical biological relationships among protein families, clans, and functional annotations. Here, we introduce

Indexed as

Computational BiologyMachine LearningProtein Interaction MappingProtein Interaction MapsAnimalsDatabases, ProteinHost-Pathogen InteractionsPrediction Algorithmscontrastive learningcross-species predictionhost–pathogen interactionprotein familyprotein–protein interaction

Identifiers

PMID42511585
PMCPMC13410131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.