Evidence map›Paper›PMID 42511573›Full record

ArticleInternational journal of molecular sciences2026

Evolution of Recurrent Myxofibrosarcoma of the Thoracic Wall at Single-Cell Resolution: A Case Report.

Elena E Kopantseva, Artem L Toropov, Timur I Fetisov, Alexander V Ikonnikov, Alexandra V Sentyabreva, Maxim E Menyailo, Anastasia A Tararykova, Polina A Shtompel, Victoria Y Zinovieva, Kirill I Kirsanov and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena E KopantsevaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-5618-4588
Artem L ToropovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Timur I FetisovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Alexander V IkonnikovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0009-0009-6514-3997
Alexandra V SentyabrevaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0001-5064-219X
Maxim E MenyailoResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Anastasia A TararykovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-5548-3295
Polina A ShtompelResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Victoria Y ZinovievaN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.
Kirill I KirsanovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-8599-6833
Evgeny V DenisovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Marianna G YakubovskayaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-9710-8178

Funding

Russian Science Foundation Grant #23-65-00003
6 · The paper itself

Abstract

Myxofibrosarcoma (MFS) is a common yet understudied type of soft tissue sarcoma. It is characterized by diverse cellular morphology, unusual growth patterns, and a propensity for local tumor recurrences. A 76-year-old patient underwent multiple surgical removals of MFS recurrences of the thoracic cavity and surrounding tissues with the subsequent development of metastases. Single-cell RNA sequencing was used to analyze the earlier (R7) and later (R8) MFS recurrences, with R8 removed less than a year before the detection of metastases in the lungs. The earlier MFS recurrence displays tumor clusters with multiple immunomodulatory markers (

Indexed as

FibrosarcomaNeoplasm Recurrence, LocalThoracic WallAgedBiomarkers, TumorFemaleHumansSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisBiomarkers, Tumormetastasismyxofibrosarcomarecurrencesingle-cell RNA sequencingsoft tissue sarcomatranscriptome

Identifiers

PMID42511573
PMCPMC13410272

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.