Evidence map›Paper›PMID 42511509›Full record

ArticleInternational journal of molecular sciences2026

Investigating the Mechanisms Underlying Cell Death Induction by a Tributyltin Molecule in HTLV-1-Infected Cells Dependent or Not on IL-2 as a Growth Factor.

Valeria Stefanizzi, Evariste Molimbou, Emanuela Balestrieri, Antonella Minutolo, Franca M Cordero, Sandro Grelli, Antonio Mastino, Claudia Matteucci, Beatrice Macchi, Francesca Marino-Merlo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valeria StefanizziDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0009-0002-4192-7497
Evariste MolimbouDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0009-0004-8359-3178
Emanuela BalestrieriDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Antonella MinutoloDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-4784-4297
Franca M CorderoDepartment of Organic Chemistry "Ugo Schiff", University of Florence, 50121 Florence, Italy.ORCID 0000-0001-6005-5941
Sandro GrelliDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-1028-3203
Antonio MastinoThe Institute of Translational Pharmacology, Consiglio Nazionale delle Ricerche (C.N.R.), 00133 Rome, Italy.ORCID 0000-0002-0338-6450
Claudia MatteucciDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-6058-1092
Beatrice MacchiDepartment of Chemical Science and Technology, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-0878-1799
Francesca Marino-MerloDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-7898-583X

Funding

Ministero dell'università e della ricerca PRIN2022_EU_2022W97H54_003-CUP J53D23001200006.
6 · The paper itself

Abstract

Human T-Lymphotropic virus type 1 (HTLV-1) lifelong infects at least 5-10 million people worldwide, a minority of whom develop severe lethal diseases including adult T-cell Leukemia/lymphoma and HTLV-1-associated myelopathy or tropical spastic paraparesis. Currently, no vaccines or curative therapies to fight HTLV-1 infection or diseases are available. Recently we found that a tributyltin molecule, Bu

Indexed as

HTLV-I InfectionsHuman T-lymphotropic virus 1Interleukin-2Trialkyltin CompoundsApoptosisCell DeathCell LineHumansLeukemia-Lymphoma, Adult T-CellInterleukin-2Trialkyltin Compoundstributyltinadult T-cell leukemia/lymphomacell deathHBZHTLV-1organotin compoundsviral oncogenesis

Identifiers

PMID42511509
PMCPMC13410192

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.