Evidence map›Paper›PMID 42511504›Full record

ArticleInternational journal of molecular sciences2026

Amyloid Precursor Protein Processing Links Female Urgency Urinary Incontinence with Alzheimer's Disease: Implications for Treatment.

Wilke M Post, Joanna Widomska, Egbert Oosterwijk, Ward De Witte, Dorien M Tiemessen, Cornelius J H M Klemann, Il Hyun Ruisch, Marieke J H Coenen, Dick A W Janssen, Frank Martens and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wilke M PostDepartment of Obstetrics and Gynecology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-9126-0072
Joanna WidomskaDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
Egbert OosterwijkDepartment of Urology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-5049-0018
Ward De WitteDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
Dorien M TiemessenDepartment of Urology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Cornelius J H M KlemannDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4789-0541
Il Hyun RuischDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-4069-8509
Marieke J H CoenenDepartment of Clinical Chemistry, ErasmusMC, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8796-2031
Dick A W JanssenDepartment of Urology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Frank MartensDepartment of Urology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5883-7116
Megan U CarnesGenomics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, Durham, NC 27713, USA.
Jesse A MarksGenomics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, Durham, NC 27713, USA.ORCID 0000-0002-8159-3594
Grier P PageRTI International, Research Triangle Park, Atlanta, GA 30341, USA.ORCID 0000-0003-2582-3786
Holly E RichterDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0001-7741-5771
Rufus CartwrightDepartment of Gynaecology, Chelsea and Westminster NHS Foundation Trust, London SW10 9NH, UK.
Vatche A MinassianDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Laurent F ThomasHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-0548-2486
Anne H SkogholtDepartment of Public Health and Nursing, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Signe N StafneDepartment of Public Health and Nursing, Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-4922-477X
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Kirsten B KluiversDepartment of Obstetrics and Gynecology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-4681-4304
Geert PoelmansDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.

Funding

A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
GWAS of Hormone Treatment and CVD and Metabolic Outcomes in the WHIU01HG005152 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI REINER, ALEXANDER P · 2009 to 2011
$2.6M
Randomized Clinical Trials - Whole Genome Studies Coordinating CenterU01HG005157 · NHGRI · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J, WEIR, BRUCE S. · 2009 to 2011
$2.4M
European Fund for Regional Development (EFRD) PROJ00787 (DIABIP)NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG005152NHGRI NIH HHS U01 HG005157NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018C
6 · The paper itself

Abstract

Urgency urinary incontinence (UUI) and Alzheimer's disease (AD) are highly comorbid conditions in women, but the underlying molecular mechanisms are largely unknown. Therefore, we used network enrichment analyses and an elaborate literature search to integrate the most significant genes from four genome-wide association studies (GWASs) and other genetic, expression and functional evidence into a molecular landscape of female UUI. This molecular landscape centers around local, i.e., bladder-based, processing of the AD-associated amyloid precursor protein (APP). To further elucidate how APP processing is implicated in the comorbidity between UUI and AD, we conducted polygenic risk score (PRS)-based analyses, which showed that genetic risk factors associated with AD and a decreased amyloid beta 42/40 blood level ratio (also) contribute to UUI susceptibility. In conclusion, APP processing constitutes a putative molecular link between UUI and AD, adding further weight to their clinical comorbidity and having implications for the treatment (and prevention) of both traits.

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorUrinary Incontinence, UrgeAmyloid beta-PeptidesFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansPolymorphism, Single NucleotideAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAlzheimer’s diseaseamyloid precursor protein (APP) processingmolecular landscapeurgency urinary incontinence (UUI)

Identifiers

PMID42511504
PMCPMC13409906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.