Evidence map›Paper›PMID 42511482›Full record

ArticleInternational journal of molecular sciences2026

Global Adam17 Deficiency Preserves Renal Function and Modulates Integrated Pathogenic Responses in Experimental Diabetic Kidney Disease.

Marta Riera, Claudia Martyn, Jordi Pujol-Brugués, Eva Márquez, Eva Rodríguez, Vanesa Palau, María José Soler, Javier Gimeno, Juan Sebastián Salazar Castañeda, Melissa Pilco and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marta RieraHospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0000-0003-4362-7965
Claudia MartynHospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0009-0003-3705-3093
Jordi Pujol-BruguésHospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0009-0005-8539-2203
Eva MárquezHospital del Mar Research Institute, 08003 Barcelona, Spain.
Eva RodríguezHospital del Mar Research Institute, 08003 Barcelona, Spain.
Vanesa PalauHospital del Mar Research Institute, 08003 Barcelona, Spain.
María José SolerNephrology Department, Hospital Universitari Vall D'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-3621-0766
Javier GimenoDepartment of Pathology, Hospital del Mar, 08003 Barcelona, Spain.
Juan Sebastián Salazar CastañedaNephrology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0009-0007-5870-0228
Melissa PilcoNephrology Department, Hospital del Mar, 08003 Barcelona, Spain.
Jimena Del RiscoNephrology Department, Hospital del Mar, 08003 Barcelona, Spain.
Marta CrespoHospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0000-0001-6992-6379
Clara BarriosHospital del Mar Research Institute, 08003 Barcelona, Spain.

Funding

Instituto de Salud Carlos III PI14/00557Instituto de Salud Carlos III PI22/00006Instituto de Salud Carlos III RD21/0005/0022Instituto de Salud Carlos III RD24/0004/0003Instituto de Salud Carlos III RD24/0004/0031
6 · The paper itself

Abstract

Diabetic kidney disease (DKD) progression results from complex interactions between metabolic stress, inflammatory activation, maladaptive intracellular signalling, and fibrotic remodelling. While previous studies demonstrated renoprotective effects of cell-specific

Indexed as

ADAM17 ProteinDiabetes Mellitus, ExperimentalDiabetic NephropathiesKidneyAnimalsFibrosisGlomerular Filtration RateMaleMiceMice, KnockoutSignal TransductionADAM17 ProteinAdam17 protein, mouseAdam17diabetic nephropathyfibrosisinflammationoxidative stress

Identifiers

PMID42511482
PMCPMC13410776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.