Evidence map›Paper›PMID 42511477›Full record

ArticleInternational journal of molecular sciences2026

Integrated Cytokine, Metabolic, and Proliferative Profiling Reveals Divergent Metabolic and Proliferative Responses in Papillary Thyroid Cancer Cells.

Angelika Buczyńska-Backiel, Julia Redlińska, Julia Zając, Maria Kościuszko, Agnieszka Adamska, Katarzyna Siewko, Anna Popławska-Kita, Adam Jacek Krętowski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angelika Buczyńska-BackielClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0001-7403-6928
Julia RedlińskaDepartment of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Białystok, 15-276 Białystok, Poland.
Julia ZającDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Maria KościuszkoDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Agnieszka AdamskaDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Katarzyna SiewkoDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Anna Popławska-KitaDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0003-2627-4213
Adam Jacek KrętowskiClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0002-4522-4978

Funding

Medical University of Bialystok SUB.B. 26. 547NCN 2023/07/X/NZ7/01746
6 · The paper itself

Abstract

Papillary thyroid cancer (PTC) exhibits Warburg-type metabolic reprogramming with enhanced glycolysis and dependence on glucose-driven pathways. This study evaluated the effects of antihyperglycemic interventions on cytokine secretion, angiogenic signaling, metabolic activity, and proliferation in thyroid-derived cell models. Two PTC cell lines (MDA-T32 and SCC147) and a normal thyroid line (Nthy-ori) were analyzed for intracellular and extracellular cytokines, secretion efficiency (index), relative metabolic index (RMI), and marker of proliferation (Ki-67) expression following exposure to vandetanib (VDT), sodium-glucose cotransporter 2 (SGLT2), or dipeptidyl peptidase (DPP) inhibitors. Baseline analysis revealed distinct cell line-specific profiles. Compared with Nthy-ori cells, MDA-T32 cells exhibited increased vascular endothelial growth factor (VEGF) concentrations in lysates and conditioned medium (

Indexed as

CytokinesThyroid Cancer, PapillaryThyroid NeoplasmsCell Line, TumorCell ProliferationHumansMetabolic ReprogrammingPiperidinesQuinazolinesSodium-Glucose Transporter 2Vascular Endothelial Growth Factor ACytokinesPiperidinesQuinazolinesSodium-Glucose Transporter 2vandetanibVascular Endothelial Growth Factor AangiogenesiscytokinesDPP inhibitioninflammationmetabolismpapillary thyroid cancerSGLT2 inhibition

Identifiers

PMID42511477
PMCPMC13411649

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.