Evidence map›Paper›PMID 42511465›Full record

ArticleInternational journal of molecular sciences2026

Synthesis, Biological Evaluation, Molecular Docking and Molecular Dynamics of Substituted Thieno[2,3-d]pyrimidine Derivatives as Potential Anti-Alzheimer Agents.

Asma K Alshamari, Nourhan Magdy, Ebtesam A Basiony, Nasser A Hassan, Odeh A O Alshammari, Adel A-H Abdel-Rahman, Nuha O S Alsaif, Mona Z Alshammari, Ahmed A Elrashedy, Allam A Hassan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Asma K AlshamariDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.ORCID 0000-0001-8949-856X
Nourhan MagdyDepartment of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Ebtesam A BasionyDepartment of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Nasser A HassanDepartment of Photochemistry, Synthetic Unit, Chemical Industries Research Institute, National Research Centre, 33 El Buhouth Street, Cairo P.O. Box 12622, Egypt.ORCID 0000-0003-1809-9232
Odeh A O AlshammariDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.ORCID 0000-0003-1176-7103
Adel A-H Abdel-RahmanDepartment of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Nuha O S AlsaifDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.ORCID 0009-0003-9161-746X
Mona Z AlshammariDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.
Ahmed A ElrashedyNatural and Microbial Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth Street, Cairo P.O. Box 12622, Egypt.
Allam A HassanDepartment of Chemistry, Faculty of Science, Suez University, Suez 43221, Egypt.ORCID 0000-0002-3123-1026

Funding

University of Ha'il RG-23 108
6 · The paper itself

Abstract

Thienopyrimidine derivatives are emerging as potent scaffolds for cholinesterase inhibition in Alzheimer's disease therapy. In this work, a novel series of substituted thieno[2,3-d]pyrimidines was synthesized via Gewald's reaction, followed by cyclization and functionalization through nucleophilic substitution and hydrazone formation. Structural confirmation was achieved using spectroscopic techniques, and biological evaluation was performed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with donepezil and rivastigmine as reference drugs. Compound 4 emerged as the most potent and selective AChE inhibitor (IC

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsMolecular Docking SimulationPyrimidinesAcetylcholinesteraseButyrylcholinesteraseHumansMolecular Dynamics SimulationStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsPyrimidinesthieno(2,3-d)pyrimidineacetylcholinesterase inhibitionAlzheimer’s diseasebutyrylcholinesterasedual inhibitorsMM/GBSAmolecular dockingmolecular dynamicsSAR analysisthieno[2,3-d]pyrimidineβ-enaminonitriles

Identifiers

PMID42511465
PMCPMC13411822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.