Evidence map›Paper›PMID 42511450›Full record

ArticleInternational journal of molecular sciences2026

Signals in Peripheral Blood: Tracking Redox Status and DNA Damage Response During the Progression of Multiple Myeloma.

Panagiotis Malamos, Elisavet Deligianni, Konstantinos Koutoulogenis, Julie Courraud, Christine-Ivy Liacos, Eirini Solia, Evangelos Terpos, Meletios A Dimopoulos, Efstathios Kastritis, Vassilis L Souliotis

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Panagiotis MalamosInstitute of Chemical Biology, National Hellenic Research Foundation, 116 35 Athens, Greece.ORCID 0000-0002-5771-5352
Elisavet DeligianniInstitute of Chemical Biology, National Hellenic Research Foundation, 116 35 Athens, Greece.
Konstantinos KoutoulogenisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 176 76 Athens, Greece.ORCID 0000-0003-0778-6694
Julie CourraudDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0002-6797-7129
Christine-Ivy LiacosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0002-5412-7272
Eirini SoliaDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-9021-3824
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-5133-1422
Meletios A DimopoulosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-8990-3254
Efstathios KastritisDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-8191-5832
Vassilis L SouliotisInstitute of Chemical Biology, National Hellenic Research Foundation, 116 35 Athens, Greece.ORCID 0000-0002-2945-1329

Funding

European Union No. 101097094
6 · The paper itself

Abstract

Alterations in the redox status and the DNA damage response (DDR) parameters are early, mechanistically interconnected drivers of carcinogenesis. Herein, we investigated whether such alterations, arising during the progression of Multiple Myeloma (MM), are systemically reflected in peripheral blood mononuclear cells (PBMCs). Redox status, expressed as the GSH/GSSG ratio, and DDR-related parameters, including baseline DNA damage, efficiency of key DNA repair pathways, namely nucleotide excision repair (NER) and double-strand break repair (DSB/R), as well as apoptotic sensitivity, were evaluated in PBMCs from 17 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS), 20 with smoldering MM (SMM), and 19 with MM. PBMCs from 20 healthy controls (HCs) were analyzed in parallel. Baseline DNA damage levels and DNA repair capacities across all examined pathways increased progressively in the following order: HC < MGUS < SMM < MM (

Indexed as

DNA DamageLeukocytes, MononuclearMultiple MyelomaAgedApoptosisDisease ProgressionDNA Breaks, Double-StrandedDNA RepairExcision RepairFemaleGlutathioneHumansMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceOxidation-ReductionGlutathioneapoptotic sensitivitychromatin condensationDNA damage response (DDR)double-strand breaks repairmelphalanmultiple myelomamyelomagenesisnucleotide excision repair (NER)peripheral blood mononuclear cells (PBMCs)redox status

Identifiers

PMID42511450
PMCPMC13411237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.