Evidence map›Paper›PMID 42511285›Full record

ArticleFoods (Basel, Switzerland)2026

From Biofortification to HT-29 Growth Inhibition: Selenium-Enriched Sunflower Sprouts Modulate Apoptosis- and Cell Cycle-Related Markers.

Piyanete Chantiratikul, Anut Chantiratikul, Yada Laotongsan, Gondanai Lasungneon, Worachot Saengha, Thipphiya Karirat, Piyathida Promjamorn, Nyuk Ling Ma, Vijitra Luang-In

Abstract read
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In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Piyanete ChantiratikulDepartment of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.ORCID 0000-0003-4033-8703
Anut ChantiratikulDepartment of Agricultural Technology, Faculty of Technology, Mahasarakham University, Kantharawichai District, Maha Sarakham 44150, Thailand.ORCID 0000-0002-8313-5802
Yada LaotongsanDepartment of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.
Gondanai LasungneonNatural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.
Worachot SaenghaNatural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.
Thipphiya KariratNatural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.
Piyathida PromjamornNatural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.
Nyuk Ling MaBIOSES Research Interest Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.ORCID 0000-0002-1301-4730
Vijitra Luang-InNatural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand.ORCID 0000-0002-5009-5058

Funding

Mahasarakham University Not applicable
6 · The paper itself

Abstract

Selenium biofortification of edible sprouts is a promising strategy to enhance the cancer cell growth-inhibitory potential of plant-based foods. This study investigated the effects of selenium (Se)-enriched sunflower sprout extracts on human colorectal adenocarcinoma HT-29 cells in comparison with non-enriched sprouts. Cytotoxicity was evaluated by MTT assay, clonogenic survival by colony formation assay, wound closure by wound-healing assay, apoptosis- and cell cycle-related gene expression by qRT-PCR, and protein expression by Western blotting. Metabolite profiles were characterized using LC-MS/MS-based untargeted metabolomics. Se enrichment markedly enhanced cytotoxicity, reducing the IC

Indexed as

colorectal cancer cell linecytotoxicityHelianthus annuus L.metabolomicsselenium biofortificationwound closure inhibition

Identifiers

PMID42511285
PMCPMC13408742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.