Purification and Characterization of Novel Collagen Peptides from

Haodong Liu, Linjing Zhang, Zhiyong Zeng, Xin Wang, Bo Li

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haodong LiuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Linjing ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Zhiyong ZengCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Xin WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Bo LiCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.ORCID 0000-0003-2726-2900

Funding

2026 Beijing Innovation Team Project of the Modern Agricultural Industrial Technology System BAIC07-2026-13

6 · The paper itself

Abstract

Rainbow trout is produced in large quantities worldwide, generating substantial processing by-products, among which collagen-rich skin and bone require high-value utilization. Rainbow trout collagen peptides potentially exhibit antiplatelet activity based on structural similarity to reported antiplatelet fish collagen peptides, while their active peptide sequences and underlying mechanisms require investigation. In this study, rainbow trout skin collagen was hydrolyzed by neutral protease, yielding a hydrolysate with 70.52% inhibition of platelet aggregation at 4 mg/mL. The fraction with high antiplatelet activity, N2-2, was obtained via separation by ODS-C18 and Sephadex LH-20 chromatography, which was enriched in Gly, Pro, and Hyp residues and characterized by mild hydrophilicity and a moderate molecular weight. Peptide sequences in the N2-2 were identified by HPLC-MS/MS, followed by molecular docking-based screening, and the four peptides selected were synthesized and evaluated for antiplatelet activity in vitro. Peptides MTGP and OOGGHG exhibited higher antiplatelet activity, with IC

Indexed as

bioactive peptidesmolecular dockingP2Y12 receptorplatelet aggregation inhibitionrainbow trout

Identifiers

PMID42511252

DOI10.3390/foods15142507

PMCPMC13409523

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.