Evidence map›Paper›PMID 42510988›Full record

ArticleCurrent issues in molecular biology2026

Mutational Landscape of

Henna Ali, Tyler Gengnagel, Salem Birkholz, Gowri Vadmal, Elijah Torbenson, Beau Hsia, Abubakar Tauseef, Peter T Silberstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Henna AliSchool of Medicine, Creighton University, Omaha, NE 68178, USA.ORCID 0009-0001-3124-6666
Tyler GengnagelSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Salem BirkholzSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Gowri VadmalSchool of Medicine, Creighton University, Omaha, NE 68178, USA.ORCID 0000-0002-2549-8496
Elijah TorbensonSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Beau HsiaSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0009-0009-6403-502X
Abubakar TauseefSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Peter T SilbersteinSchool of Medicine, Creighton University, Omaha, NE 68178, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMATERIALS AND

methodsA retrospective pan-cancer analysis was performed using the AACR Project GENIE v12 database via cBioPortal. Tumors with somatic

resultsA total of 4565 tumor samples (4283 patients) were analyzed.

conclusionsFGFR4 alterations occur across a broad range of cancers with consistent domain-level patterns. The hotspot 401 mutation shows a higher mutation burden and co-alteration frequency driven largely by a subset of hypermutated tumors, rather than acting as an isolated driver.

Indexed as

AACR Project GENIEFGFR4fibroblast growth factor receptorpan-cancer analysisprecision oncologyreceptor tyrosine kinasesomatic mutationtumor mutational burden

Identifiers

PMID42510988
PMCPMC13407695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.