Evidence map›Paper›PMID 42510971›Full record

ArticleCurrent issues in molecular biology2026

p53 and p21 Status Influences Cellular Response to Metformin in

Asma Saeed, Jamila Hijazi, Zainab Bashir, Pierre Khoueiry, Assaad A Eid, Nadine Darwiche, Maria Teresa Bengoechea-Alonso, Johan Ericsson, Borbala I Mifsud, Georges Nemer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Asma SaeedCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.
Jamila HijaziDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 110236, Lebanon.ORCID 0009-0008-0034-0386
Zainab BashirCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.ORCID 0000-0003-2687-1165
Pierre KhoueiryDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 110236, Lebanon.
Assaad A EidDepartment of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 110236, Lebanon.
Nadine DarwicheDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 110236, Lebanon.ORCID 0000-0002-1862-5426
Maria Teresa Bengoechea-AlonsoCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.ORCID 0009-0006-4210-6999
Johan EricssonCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.
Borbala I MifsudCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.ORCID 0000-0003-3429-3094
Georges NemerCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.ORCID 0000-0003-2157-5279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer morbidity worldwide, highlighting the need for improved therapies. Metformin, a widely used antihyperglycemic agent, has gained attention for its potential antitumor properties. In this study, we evaluated the effects of the tumor suppressor genes

Indexed as

colorectal cancerHCT116KRASmetforminp21p53transcriptomic analysistumor suppressor gene

Identifiers

PMID42510971
PMCPMC13408822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.