Evidence map›Paper›PMID 42510965›Full record

ArticleCurrent issues in molecular biology2026

VEGF Expression in Head and Neck Squamous Cell Carcinoma: Association with TNM Staging and Tumor Progression.

Cristina Stefania Dumitru, Alina Cristina Barb, Antonia Armega Anghelescu, Dorin Novacescu, Marina Rakitovan, Cristian Silviu Suciu, Flavia Zara

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In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina Stefania DumitruDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0001-8933-3060
Alina Cristina BarbDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Antonia Armega AnghelescuDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Dorin NovacescuDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-2520-7636
Marina RakitovanDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Cristian Silviu SuciuDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Flavia ZaraDepartment II of Microscopic Morphology, Discipline of Histology, "Victor Babes" University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-5755-179X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional TNM staging in head and neck squamous cell carcinoma (HNSCC) does not fully capture the molecular heterogeneity driving tumor aggressiveness. Identifying accessible biomarkers that complement staging is therefore a clinical priority. This retrospective study evaluated immunohistochemical VEGF expression in 50 histopathologically confirmed HNSCC cases and examined its association with TNM staging and clinicopathological parameters. VEGF expression was assessed using a semi-quantitative immunoreactivity score (IRS; range 0-12; median 5; IQR 3-8). High VEGF expression (IRS ≥ 4) was identified in 64% of cases and was significantly associated with advanced tumor stage (III-IV;

Indexed as

angiogenesisclinicopathological featureshead and neck squamous cell carcinomaimmunohistochemistryTNM stagingtumor progressionVEGF

Identifiers

PMID42510965
PMCPMC13409531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.