Evidence map›Paper›PMID 42510940›Full record

ArticleCurrent issues in molecular biology2026

Between Chemical Simplicity and Biological Complexity: In Silico Profiling of Butyrolactones I and III as Potential Multi-Target Drug Candidates.

Tomasz Kowalczyk, Anna Merecz-Sadowska, Belma Konuklugil, İbrahim Seyda Uras, Radosław Zajdel, Patricia Rijo, Przemysław Sitarek

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tomasz KowalczykDepartment of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0002-4559-5015
Anna Merecz-SadowskaDepartment of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.ORCID 0000-0001-9987-4573
Belma KonuklugilDepartment of Pharmacognosy, Faculty of Pharmacy, Lokman Hekim University, 06530 Ankara, Turkey.
İbrahim Seyda UrasDepartment of Pharmacognosy, Faculty of Pharmacy, Ağrı İbrahim Çeçen University, 04100 Agri, Turkey.ORCID 0000-0001-5945-8743
Radosław ZajdelDepartment of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.
Patricia RijoCBIOS-Research Center for Biosciences & Health Technologies, Universidade Lusófona, 1749-024 Lisbon, Portugal.ORCID 0000-0001-7992-8343
Przemysław SitarekDepartment of Medical Biology, Medical University of Lodz, 90-151 Lodz, Poland.ORCID 0000-0001-5495-3550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of multi-targeted therapeutic agents is increasingly recognized as essential for treating multifactorial diseases. Butyrolactone I and butyrolactone III, γ-butyrolactone derivatives isolated from the marine fungus

Indexed as

acetylcholinesteraseADMETAspergillus terreusbutyrolactone Ibutyrolactone IIIMDM2molecular dockingmolecular dynamicsmultitarget drug discoverynatural products

Identifiers

PMID42510940
PMCPMC13407958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.