Evidence map›Paper›PMID 42510840›Full record

ReviewGenes2026

A Review of the Uncertainties of Eukaryotic Translation Initiation.

Anton A Komar, William C Merrick

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anton A KomarCenter for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA.ORCID 0000-0003-4188-0633
William C MerrickDepartment of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-3009-8128

Funding

Safer and more effective FIX therapeutics: impact of codon optimizationR01HL151392 · NHLBI · CLEVELAND STATE UNIVERSITY · PI KOMAR, ANTON A. · 2020 to 2023
$1.5M
eIF2A in translational controlR01GM128981 · NIGMS · CLEVELAND STATE UNIVERSITY · PI KOMAR, ANTON A. · 2020 to 2023
$1.2M
National Heart Lung and Blood Institute HL151392NHLBI NIH HHS R01 HL151392NIGMS NIH HHS GM128981NIGMS NIH HHS R01 GM128981
6 · The paper itself

Abstract

This article proposes three possible explanations that relate to the process of eukaryotic translation initiation. These explanations suggest mechanisms as to how concentrations of initiation factors (by mass or by posttranslational modification) can influence start site selection, how regulation of translation by 4E-BP (an inhibitor of m

Indexed as

Peptide Chain Initiation, TranslationalAnimalsEukaryotic Initiation Factor-4FEukaryotic Initiation FactorsHumansProtein BiosynthesisRNA, MessengerEukaryotic Initiation Factor-4FEukaryotic Initiation FactorsRNA, MessengerATPeIF4AeIF4F disassemblyequilibrium in assemblyinitiation factorinitiation of eukaryotic protein synthesismRNAribosomescanning

Identifiers

PMID42510840
PMCPMC13409590

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.