Evidence map›Paper›PMID 42510769›Full record

ArticleGenes2026

Oligonucleotide Synthesis Errors Are a Source of Untoward Variation in HDR-Mediated Gene Editing.

Stacia K Wyman, Zulema Romero, Seok-Jin Heo, Marian Navarrete, Netravathi Krishnappa, Donald B Kohn, David I K Martin, Mark C Walters, Dario Boffelli

Abstract read
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Stacia K WymanInnovative Genomics Institute, University of California, Berkeley, CA 94720, USA.
Zulema RomeroDepartments of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-8305-8184
Seok-Jin HeoLaboratory for Genomics Research, Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.ORCID 0009-0004-4830-8319
Marian NavarreteDepartments of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Netravathi KrishnappaInnovative Genomics Institute, University of California, Berkeley, CA 94720, USA.
Donald B KohnDepartments of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-1840-6087
David I K MartinUCSF Benioff Children's Hospital Oakland, Oakland, CA 94609, USA.
Mark C WaltersUCSF Benioff Children's Hospital Oakland, Oakland, CA 94609, USA.
Dario BoffelliDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA 90069, USA.

Funding

Cure Sickle CellOT3HL147741 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MARY EAPEN, Mary Maresca Horowitz · 2018 to 2026
$37.7M
Curing Sickle Cell Disease with CRISPR-Cas9 genome editingOT2HL151319 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WALTERS, MARK C · 2019 to 2021
$2.2M
California Institute for Regenerative Medicine CLIN1-11497California Institute for Regenerative Medicine CLIN2-11722California Institute for Regenerative Medicine TRAN1-09292National Heart Lung and Blood Institute HL151319National Heart Lung and Blood Institute OT3HL147741NHLBI NIH HHS OT2 HL151319NHLBI NIH HHS OT3 HL147741
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene EditingOligonucleotidesRecombinational DNA RepairAnemia, Sickle Cellbeta-GlobinsCRISPR-Cas SystemsHematopoietic Stem CellsHigh-Throughput Nucleotide SequencingHumansbeta-GlobinsOligonucleotidesDNA synthesisgene editingsickle cell diseasesingle-stranded oligonucleotide

Identifiers

PMID42510769
PMCPMC13409629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.