ArticleBiology2026
Recovery of Hindlimb Motor Function Is Accompanied by Lumbar Neural Remodeling After Complete Spinal Cord Transection in Neonatal Mice.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Spinal cord injury often causes persistent neurological dysfunction, whereas the developing central nervous system retains greater plasticity. This study investigated whether spontaneous hindlimb motor recovery occurs after complete spinal cord transection in neonatal mice and whether such recovery is accompanied by structural remodeling of the lumbar spinal cord distal to the lesion. C57BL/6J mice underwent complete T9 spinal cord transection at postnatal day 7, and recovery was assessed by Basso Mouse Scale scoring, CatWalk gait analysis, foot-fault testing, immunofluorescence, and electromyography. Compared with adult mice subjected to the same injury, neonatal mice showed progressive partial improvement in hindlimb motor function, including locomotor performance, gait coordination, and foot placement accuracy. Meanwhile, this recovery was accompanied by preservation of lumbar motor neurons and structural changes in the local neural network. Syn
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