Evidence map›Paper›PMID 42510738›Full record

ArticleBiology2026

Life-Cycle Diphenyl Phosphate (DPhP) Exposure Reveals Sex-Differential Functional Alterations in the Zebrafish Gut Microbiota.

Tong Zhou, Ruiqi He, Ya Li, Yuwei Xie, Linyan Deng, Meng Xia, Xiaolong Lian, Jingjing An, Yufeng Gong, Qiliang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tong ZhouChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Ruiqi HeChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Ya LiChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Yuwei XieNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing 210042, China.ORCID 0000-0001-5652-6413
Linyan DengChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Meng XiaChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Xiaolong LianChongqing International Institute for Immunology, Chongqing 401338, China.
Jingjing AnChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.
Yufeng GongCollege of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Qiliang ChenChongqing Key Laboratory of Conservation and Utilization of Freshwater Fishes, Animal Biology Key Laboratory of Chongqing Education Commission of China, Chongqing Normal University, Chongqing 401331, China.

Funding

National Natural Science Foundation of China 31901183
6 · The paper itself

Abstract

Fish gut microbiota is essential for maintaining host physiological health but is constantly threatened by environmental chemicals. Diphenyl phosphate (DPhP), a major degradation product of organophosphate flame retardants and an environmental pollutant widely detected in aquatic ecosystems, is a chemical of emerging concern; however, few studies have addressed its effects on the gut microbiota. In this study, zebrafish were exposed to environmentally relevant concentrations of DPhP (0.8, 3.9, or 35.6 μg/L) from the embryonic stage to adulthood over 120 days. Using V3-V4 region 16S rRNA gene sequencing and functional gene prediction, we systematically analyzed the sex-specific responses of the gut microbiota. The results showed that life-cycle DPhP exposure exerts markedly different effects on the gut microbiota of male and female zebrafish. In females, DPhP induced concentration-dependent, stepwise Tax4Fun2 predicted functional shifts suggestive of compensation: at the low concentration (0.8 μg/L), energy metabolism and cofactor/vitamin metabolism functions were predicted to be enhanced; at the medium concentration (3.9 μg/L), Fusobacteria (mainly

Indexed as

16S rRNA gene sequencingdiphenyl phosphatefunctional predictiongut microbiotasex differenceszebrafish

Identifiers

PMID42510738
PMCPMC13405081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.