Evidence map›Paper›PMID 42510708›Full record

ArticleBiology2026

Porcine Interleukin-2, IL-4 and IL-6 Combined with a Colloidal Manganese Adjuvant Enhance PCV2-Mhp Bivalent Inactivated Vaccine Immunogenicity in Mice.

Junjie Peng, Linhan Zhang, Dafang He, Gang Wang, Jianglin Li, Shanshan Zhu, Rong Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junjie PengNational Engineering Research Center for Biomaterial, Sichuan University, Chengdu 610065, China.ORCID 0000-0001-7303-2562
Linhan ZhangKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.ORCID 0000-0001-5172-2247
Dafang HeKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.
Gang WangNational Engineering Research Center for Biomaterial, Sichuan University, Chengdu 610065, China.ORCID 0000-0003-3296-3015
Jianglin LiSichuan Academy of Animal Science, Chengdu 610066, China.
Shanshan ZhuSichuan University Library, Sichuan University, Chengdu 610065, China.
Rong GaoKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.ORCID 0009-0001-7954-4910

Funding

Chengdu International Technology Innovation Cooperation Program (2025-GH02-00035-HZ) 2025-GH02-00035-HZkey project of Sichuan University, sanyoukang Corp 23H1442the Sichuan Provincial bueau of Sicence & Technology of China 2020YFH0020, 2021YFYZ0030
6 · The paper itself

Abstract

Porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae (Mhp) are major contributors to the porcine respiratory disease complex. Although PCV2-Mhp bivalent inactivated vaccines are useful for simultaneous disease control, their immunogenicity may be improved by adjuvant optimization. This study evaluated a composite adjuvant consisting of porcine interleukin-2 (IL-2), IL-4, IL-6 and MnJ(beta), a colloidal manganese adjuvant, in an initial murine immunogenicity model. Thirty female Kunming mice were assigned to three groups (

Indexed as

bivalent inactivated vaccinecytokine adjuvantIL-2IL-4IL-6MnJ(beta)murine modelMycoplasma hyopneumoniaePCV2

Identifiers

PMID42510708
PMCPMC13404460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.