Evidence map›Paper›PMID 42510680›Full record

ArticleBiology2026

Distinct Basal Gut Microbiota Profiles Are Associated with Strain-Specific Lung Responses to

Dusanka Popovic, Ivana Mirkov, Dina Tucovic, Aleksandra Popov Aleksandrov, Anastasija Malesevic, Stanislava Stanojevic, Jasmina Glamoclija, Maja Tolinacki, Milica Zivkovic, Jelena Kulas

Abstract read
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In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dusanka PopovicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Ivana MirkovImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Dina TucovicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Aleksandra Popov AleksandrovImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-9081-7481
Anastasija MalesevicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Stanislava StanojevicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-9209-3851
Jasmina GlamoclijaDepartment of Plant Physiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6823-1137
Maja TolinackiGroup for Probiotics and Microbiota-Host Interaction, Department of Microbiology and Plant Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, Serbia.
Milica ZivkovicGroup for Probiotics and Microbiota-Host Interaction, Department of Microbiology and Plant Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, Serbia.
Jelena KulasImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

Funding

Ministry of Science, Technological Development, and Innovation 451-03-33/2026-03/ 200007Ministry of Science, Technological Development, and Innovation 451-03-66/2024-03/200042
6 · The paper itself

Abstract

backgroundAntibiotic-associated gut dysbiosis affects lung health and contributes to disease progression, but the individual response to antibiotics, which leads to host-specific reactions to the same respiratory insult, is not fully understood.

methodsBefore infection with

resultsTreatment with antibiotics induced gut inflammation in both rat strains, which was more pronounced in AO rats, and a disturbance in lung immunity was observed only in DA rats. Antibiotic-associated gut microbiota disturbance revealed rat strain-specific bacterial profiles (increased Gammaproteobacteria in DA and decreased Coriobacteriia in AO rats). Although gut dysbiosis increased the risk of lung

conclusionsRat strain differences in response to antibiotic- and/or infection-induced gut dysbiosis suggest that basal gut microbiota may influence the lung immune response during

Indexed as

Albino Oxford (AO) rat strainantibioticsAspergillus fumigatus lung infectionDark Agouti (DA) rat straingut microbiotainflammationlung microbiotanext generation sequencing

Identifiers

PMID42510680
PMCPMC13404131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.