ArticleBiology2026
Integrated ATAC-Seq and RNA-Seq Identify ATF3 as a Tumor Suppressor in UVB-Induced Keratinocyte Carcinogenesis.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Current approaches for preventing and suppressing the initiation and development of keratinocyte carcinoma remain limited, highlighting the urgent need to identify novel targets for tumor intervention. As major environmental pathogenic factor, chronic ultraviolet B (UVB) exposure promotes keratinocyte malignant transformation through epigenetic reprogramming, reshaping chromatin accessibility and gene expression program, which has not been fully elucidated. Here, we established a chronic UVB irradiation model to induce malignant transformation of keratinocytes and performed integrative analyses using ATAC-seq and RNA-seq. We identified 4903 differentially accessible regions (DARs), with increased accessibility at loci of tumor-promoting genes such as
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