Evidence map›Paper›PMID 42510596›Full record

ReviewAntioxidants (Basel, Switzerland)2026

Hydroxysafflor Yellow A for Diabetic Retinopathy: A Critical Review of Retinal Neurovascular Mechanisms and Systemic-to-Ocular Pharmacokinetic Barriers.

Jiaqi Liu, Wenjing Liu, Lu Li, Qianqian Zhang, Jun Zhang, Wenjie Yan

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiaqi LiuCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.ORCID 0009-0002-0456-5060
Wenjing LiuCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
Lu LiCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
Qianqian ZhangCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
Jun ZhangCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
Wenjie YanCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, China.

Funding

Beijing Union University ZK10202501China National Center for Food Safety Risk Assessment SSZX-2024-BJ-03
6 · The paper itself

Abstract

Oxidative stress contributes to retinal neurovascular injury through inflammation, mitochondrial dysfunction, blood-retinal barrier (BRB) disruption, microcirculatory impairment, and regulated cell death. Hydroxysafflor yellow A (HSYA), a water-soluble quinochalcone C-glycoside derived from safflower (

Indexed as

blood–retinal barrierdiabetic retinopathydrug deliveryhydroxysafflor yellow Aocular pharmacokineticsoxidative stressretinal neurovascular unit

Identifiers

PMID42510596
PMCPMC13405865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.