Evidence map›Paper›PMID 42510585›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Promoter Hypermethylation Is Associated with Reduced Nrf2 and Antioxidant Enzyme Expression in Mandibular Condylar Cartilage in Mice.

Hisano Ujiie, Hiroyuki Kanzaki, Mao Katayama, Tomomi Ida, Syunnosuke Tohyama, Miho Shimoyama, Yuta Katsumata, Chihiro Arai, Misao Ishikawa, Hiroshi Tomonari

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hisano UjiieDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Hiroyuki KanzakiDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.ORCID 0000-0003-3473-1218
Mao KatayamaDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Tomomi IdaDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Syunnosuke TohyamaDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Miho ShimoyamaDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Yuta KatsumataDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Chihiro AraiDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Misao IshikawaDepartment of Anatomy, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.ORCID 0009-0009-1927-9201
Hiroshi TomonariDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.

Funding

Japan Society for the Promotion of Science 22K10256Japan Society for the Promotion of Science 22K10257, 22K10281, 21K10197, 21K10199, 23K09427, and 21K21026
6 · The paper itself

Abstract

Mandibular condylar cartilage (MCC) exhibits greater susceptibility to mechanical stress-induced degeneration than tibial articular cartilage (TAC). This study investigated whether differential epigenetic regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant responses, is associated with distinct antioxidant capacities between these cartilage types. Cartilage tissues from 5-week-old male ICR mice (

Indexed as

antioxidantcartilageDNA methylationepigenomemechanical stressNrf2osteoarthritispromoterreactive oxygen species (ROS)temporomandibular joint

Identifiers

PMID42510585
PMCPMC13403435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.