ReviewAntioxidants (Basel, Switzerland)2026
Toxicity Evaluation of Nano-Sized Particles by Analysis of mtDNA Content and Expression Levels of Genes Required for mtDNA Maintenance: A Meta-Analysis of Pre-Clinical Studies.
Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Mitochondrial alterations, including mitochondrial DNA (mtDNA) loss and defects in maintenance pathways, have been recognized as an important driver for toxic effects of environmental pollutants. Therefore, exposure to nano-sized particles (1-100 nm in diameter; a new source of environmental pollution) may also result in these mitochondrial impairments; however, controversial results have been reported. Available studies collected from three electronic databases through July 2025 were pooled for a comprehensive assessment. Meta-analysis of 19 in vitro studies (69 datasets) showed exposure to nano-sized particles significantly reduced mtDNA content [standardized mean difference = -1.08;
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Registered trials
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