Evidence map›Paper›PMID 42510553›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Integrin α5β1 Activation by PHSRN Peptide Elicits Neuroprotection and Functional Recovery in Parkinson's Disease Mice.

Cheng-Chun Wu, Hao-Kuang Wang, Yu-Ting Su, Yu-Cheng Ho, Yuan-Chin Hsieh, Cheng-Loong Liang, Yung-Kuo Lee, Tian-Huei Chu, Yun-Shin Lin, Jui-Sheng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheng-Chun WuGraduate Institute of Medicine, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.ORCID 0000-0002-7084-9208
Hao-Kuang WangGraduate Institute of Medicine, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.
Yu-Ting SuDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 833401, Taiwan.
Yu-Cheng HoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.
Yuan-Chin HsiehDepartment of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.
Cheng-Loong LiangSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.
Yung-Kuo LeeMedical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung City 802231, Taiwan.ORCID 0000-0003-1638-8049
Tian-Huei ChuMedical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung City 802231, Taiwan.
Yun-Shin LinDepartment of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung City 802231, Taiwan.
Jui-Sheng ChenGraduate Institute of Medicine, College of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan.ORCID 0000-0001-7627-6132

Funding

E-Da Hospital EDAHP114012, EDAHP114015, EDAHP113003, EDDHP113002, EDDHP112003, EDAHJ114010, EDAHJ113013, EDAHJ113004, EDPJ111061, EDAHP111006, EDAHP111044National Science and Technology Council NSTC 114-2320-B-214-003, NSTC 114-2314-B-214 -005 -MY3, NSTC 113-2314-B-214-009, NSTC 113-2311-B-214-001, NSTC 113-2320-B-393-001, MOST 111-2628-B-214 -001 -MY3, MOST 111-2314-B-214-009
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration driven by oxidative stress, mitochondrial dysfunction, synaptic loss, and impaired neurotrophic signaling; however, the role of integrin α5β1 in neuronal vulnerability remains unclear. Here, the data show that rotenone-induced stress reduces integrin α5 expression in a dose- and time-dependent manner, leading to increased ROS accumulation, glutathione imbalance, synaptic degeneration, senescence-like β-gal activity, and apoptosis, whereas integrin α5 knockdown further exacerbates these deficits, supporting a protective role of α5β1. In contrast, treatment with the fibronectin-derived α5β1-activating peptide Ac-PHSRN-NH

Indexed as

BDNFdopaminergic neuroprotectionintegrin α5β1NGFoxidative stressParkinson’s diseasePHSRN peptidesynaptic integrity

Identifiers

PMID42510553
PMCPMC13405216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.