Efficacy and Mechanisms of Butyric Acid Derivatives as Feed Additives in Weaned Piglet Nutrition: A Review.

Weican Zhang, An Tao, Xingping Chen, Xin Li, Tiande Zou, Jun Chen, Jinming You

Abstract readReview

In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Weican ZhangJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

An TaoJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Xingping ChenJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0002-5651-4014

Xin LiJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Tiande ZouJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Jun ChenJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0001-5037-3479

Jinming YouJiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Funding

Jiangxi Provincial Cultivation Program for Academic and Technical Leaders of Major Subjects No. 20213BCJ22005Jiangxi Provincial Natural Science Foundation No. 20242BAB25390National Key Research and Development Program of China No. 2022YFC2105005Science and Technology Research Project of the Jiangxi Provincial Department of Education No. GJJ2400310

6 · The paper itself

Abstract

Early weaning can disrupt the intestinal function and microbial community balance of piglets, and trigger inflammation and oxidative stress, thereby affecting their production performance. In recent years, butyric acid has gained considerable interest as a functional feed additive. However, practical limitations such as its pungent odor and low absorption efficiency in the digestive tract have led to the development of more stable forms, including sodium butyrate, coated butyrate, and butyrate glycerides, etc. Research has shown that butyric acid and its derivatives can serve as effective feed additives by enhancing pigs' resistance to pathogenic colonization, stabilizing the intestinal microbiota, and alleviating oxidative stress to mitigate challenges such as weaning stress and pathogenic infections. This review systematically highlights the role of butyric acid and its derivatives as dietary supplements for weaned piglets. Importantly, it underscores the potential of butyric acid and its derivatives may contribute to antibiotic-reduction strategies in weaned piglet nutrition, while also highlighting the need for optimized supplementation strategies and further investigation into synergistic effects with other feed additives. This review aims to offer both theoretical and practical insights for the application of butyric acid in weaned piglet nutrition.

Indexed as

anti-inflammatory effectsantioxidantbutyric acidfunctional feed additivegut microbiotaintestinal healthweaned pigs

Identifiers

PMID42510536

DOI10.3390/antiox15070805

PMCPMC13403749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.