Two-Year Clinical Outcome of Using Biphasic Osteochondral Constructs in the Treatment of Patients with Mild-to-Moderate-Stage Osteoarthritis of the Knee.

Chih-Yung Chiang, Po-Wei Lee, Chang-Chin Wu

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Chih-Yung ChiangDepartment of Biomedical Engineering, National Taiwan University, Taipei 106216, Taiwan.

Po-Wei LeeBioGend Therapeutics Co., Ltd., Taipei 115603, Taiwan.ORCID 0009-0004-8923-9807

Chang-Chin WuDepartment of Orthopedic Surgery, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.

Funding

This research received no external funding

6 · The paper itself

Abstract

A biphasic osteochondral construct has been developed to repair focal chondral and osteochondral lesions. This study aimed to evaluate the safety and preliminary clinical feasibility of using the biphasic osteochondral construct in treating patients having mild-to-moderate-stage knee osteoarthritis. This single-center, prospective, open-label, single-arm feasibility trial compared 2-year knee functional outcome (KOOS and IKDC scores), pain VAS score, and radiological assessment of repaired cartilage (MOCART score) after treatment versus the corresponding preoperative scores. All enrolled patients had a clinical history of primary knee osteoarthritis (OA), Kellgren Lawrence grade 1-3 without valgus or varus deformity greater than 5 degrees. Five men and three women completed the two-year follow-up, with a mean age of 53.9 ± 9.3 years (range 34-63 years). The average lesion size was 4.5 ± 2.9 cm

Indexed as

biphasic osteochondral constructcartilage repairclinical feasibilityknee osteoarthritissingle-stage autologous cartilage implantation

Identifiers

PMID42510444

DOI10.3390/bioengineering13070778

PMCPMC13404532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.