ArticleBioengineering (Basel, Switzerland)2026
In Vivo Mechanical Demands on Vertebral Body Replacements During Rehabilitation Exercises: A Multidimensional and Longitudinal Analysis.
Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMechanical complications remain a concern after vertebral body replacement (VBR), especially during rehabilitation. Yet exercise prescription is often guided by body posture or single loading measures. This study characterized mechanical demands during rehabilitation exercises after VBR and examined the effects of posture and postoperative time.
methodsTelemetric in vivo load data from instrumented VBRs in the OrthoLoad database were analyzed. A total of 119 trials across 21 exercises, performed in supine, prone, seated, and standing positions, were collected from five patients over 0.1-63 postoperative months. Mechanical demand was quantified across six biomechanical domains and integrated into a composite SafetyIndex. Posture- and time-related effects were assessed using linear mixed-effects models. Worst-case demand was defined as the 95th percentile of SafetyIndex values.
resultsSafetyIndex showed a right-skewed distribution (median 8.5, IQR 3.7-14.1), with marked inter-exercise variability. Composite SafetyIndex did not differ between postures (all
conclusionsMechanical demand after VBR is task-specific and domain-dependent and cannot be inferred from posture alone. Axial and bending-related components increased over postoperative time, whereas shear-related loading remained task-dependent.
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