Nephron-Sparing Surgery for Unilateral Non-Syndromic Wilms Tumor in a 9-Day-Old Neonate.

Silvia Ceccanti, Francesco Morini, Loredana Amoroso, Gian Marco Andreoli, Gabriele Masselli, Denis A Cozzi

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Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Silvia CeccantiPediatric Surgery Unit, Department Maternal Infantile and Urological Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-1649-1038

Francesco MoriniPediatric Surgery Unit, Department Maternal Infantile and Urological Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-5887-813X

Loredana AmorosoPediatric Oncology Unit, Department Maternal Infantile and Urological Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-1950-4754

Gian Marco AndreoliPediatric Radiology Unit, Department of Radiological, Oncological, Pathological Anatomy Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.

Gabriele MasselliEmergency Radiology Unit, Department of Radiological, Oncological, Pathological Anatomy Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

Denis A CozziPediatric Surgery Unit, Department Maternal Infantile and Urological Sciences, AOU Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-7290-3837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal renal tumors are uncommon and generally associated with an excellent prognosis. We report the youngest patient to date with unilateral non-syndromic Wilms tumor successfully treated with nephron-sparing surgery rather than radical nephrectomy, which is the current standard of care. The patient subsequently received risk-adapted chemotherapy. At 18 months of follow-up, he remains asymptomatic and with symmetric differential renal volumes, consistent with preserved bilateral renal function. This case suggests that nephron-sparing surgery, when technically feasible, may represent a safe and effective treatment option for carefully selected neonatal renal tumors, offering a functional advantage over radical nephrectomy without compromising oncologic safety.

Indexed as

neonatenephron-sparing surgerynon-syndromicradical nephrectomyWilms tumor

Identifiers

PMID42509991

DOI10.3390/children13070966

PMCPMC13406828

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