ArticleChildren (Basel, Switzerland)2026
Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAmbulatory blood pressure monitoring (ABPM) offers a comprehensive assessment of mean blood pressure (BP), circadian patterns, and out-of-office hypertension phenotypes. We evaluated the association of ABPM parameters with left ventricular hypertrophy (LVH) and hypertensive retinopathy (HRP) in children with hypertension.
methodsThis retrospective analysis included 269 children who underwent ABPM at a tertiary care facility. Multivariable logistic regression was used to evaluate associations between BP Z scores and target organ damage (TOD), adjusting for age, sex, and body mass index standard deviation score. Machine learning techniques (logistic regression, random forest, and multilayer perceptron) were also evaluated using 10-fold cross-validation across exploratory combinations of the 90th or 95th percentiles and BP-load thresholds of 25% or 50%.
resultsLVH was detected in 45/247 patients (18%) and HRP was observed in 22/240 patients (9%). The 24 h systolic BP Z score was independently associated with LVH (adjusted OR 1.44; 95% CI 1.16-1.80;
conclusionsHigher ambulatory systolic BP was independently associated with LVH but not with clinically detected hypertensive retinopathy. ABPM values at or above the 90th percentile and a systolic load of ≥25% may help identify children at increased risk of TOD, although these thresholds remain exploratory and require prospective external validation.
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