Evidence map›Paper›PMID 42509835›Full record

ArticleBiomolecules2026

p53-Dependent ENOX2 Downregulation Mediates the Apoptotic Responses to Heteroarene-Fused Anthraquinones in Colon Cancer Cells.

Chien-Yu Chen, Alexander S Tikhomirov, Yih-Farng Liou, Chi-Wen Chen, Shih-Han Chiu, Atikul Islam, Andrey E Shchekotikhin, Pin Ju Chueh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chien-Yu ChenGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.ORCID 0000-0003-2445-6128
Alexander S TikhomirovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia.ORCID 0000-0002-6418-1539
Yih-Farng LiouDepartment of Internal Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, Taichung 42055, Taiwan.
Chi-Wen ChenDepartment of Surgery, Feng-Yuan Hospital, Ministry of Health and Welfare, Taichung 42055, Taiwan.
Shih-Han ChiuGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.
Atikul IslamGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.
Andrey E ShchekotikhinGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia.ORCID 0000-0002-6595-0811
Pin Ju ChuehGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.ORCID 0000-0002-3200-7552

Funding

Feng Yuan Hospital Grant number 113-06Ministry of Health and Welfare Grant number 109-10National Science and Technology Council MOST 108-2923-B-005-001-MY3Russian Foundation for Basic Research Project 19-53-52008
6 · The paper itself

Abstract

Anthraquinone-based intercalating compounds, such as doxorubicin and mitoxantrone, have long been used clinically due to their ability to induce DNA damage. More recently, heteroarene-fused anthraquinones have been developed to further enhance their anticancer activity. Among these compounds, 4,11-bis(2-(2-chloroacetamidine)ethylamino)anthra[2,3-b]thiophene-5,10-dione dihydrochloride (designated as derivative

Indexed as

AnthraquinonesAntineoplastic AgentsApoptosisColonic NeoplasmsTumor Suppressor Protein p53Cell Line, TumorCell ProliferationDown-RegulationGene Expression Regulation, NeoplasticHCT116 CellsHumansAnthraquinonesAntineoplastic AgentsTumor Suppressor Protein p53anthraquinoneapoptosiscell cycle arrestcolon cancer cellsecto-NADH oxidase disulfide-thiol exchanger 2 (ENOX2/tNOX)heterocyclic compounds

Identifiers

PMID42509835
PMCPMC13407073

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.