Evidence map›Paper›PMID 42509834›Full record

ArticleBiomolecules2026

Chemogenetic Activation of LC Noradrenergic Afferents Facilitates Cerebellar CF-PC LTD via Presynaptic α

Xu-Dong Zhang, Ying-Han Xu, Wang-Tong Wu, Lang-Yue Zheng, Xin-Yi Xu, Chun-Ping Chu, De-Lai Qiu

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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xu-Dong ZhangDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Ying-Han XuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Wang-Tong WuInstitute of Brain Science, Jilin Medical University, Jilin City 132013, China.
Lang-Yue ZhengInstitute of Brain Science, Jilin Medical University, Jilin City 132013, China.
Xin-Yi XuInstitute of Brain Science, Jilin Medical University, Jilin City 132013, China.
Chun-Ping ChuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.ORCID 0009-0006-6921-5028
De-Lai QiuInstitute of Brain Science, Jilin Medical University, Jilin City 132013, China.

Funding

Ministry of Science and Technology of the People's Republic of China 2021ZD0202300National Natural Science Foundation of China 32171005
6 · The paper itself

Abstract

Cerebellar climbing fiber-Purkinje cell (CF-PC) long-term depression (LTD) plays a critical role in motor learning and is modulated by locus coeruleus (LC) noradrenergic afferents via distinct adrenergic receptor (AR) subtypes. Nevertheless, the mechanisms underlying LC noradrenergic neuron-mediated regulation of CF-PC LTD remain poorly understood. Here, we investigated the effects of chemogenetic activation of LC noradrenergic afferents on CF-PC LTD in cerebellar slices from dopamine β-hydroxylase (DBH)-Cre mice using electrophysiology, glutamate sensor imaging, immunofluorescence and pharmacological approaches. Tetanic stimulation (5 Hz) of CFs induced CF-PC LTD under control conditions, and this LTD was enhanced by chemogenetic activation of LC noradrenergic afferents. Blockade of group I metabotropic glutamate receptors (mGluR1) abolished LTD under control conditions, whereas chemogenetic activation of LC noradrenergic afferents triggered a novel form of CF-PC LTD accompanied by an increased N2/N1 ratio. With mGluR1 blocked, chemogenetic activation of LC noradrenergic afferents failed to trigger the novel CF-PC LTD following blockade of α

Indexed as

CerebellumCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5Locus CoeruleusLong-Term Synaptic DepressionPurkinje CellsReceptors, Adrenergic, alpha-2AnimalsChemogeneticsMaleMiceReceptors, Metabotropic GlutamateSignal TransductionAdra2a protein, mouseCdk5 protein, mouseCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5Receptors, Adrenergic, alpha-2Receptors, Metabotropic Glutamatecerebellumchemogenetic activationclimbing fiber–Purkinje cell synaptic plasticitycyclin–dependent kinase 5 (CDK5)locus coeruleusprotein kinase A (PKA)α2-adrenergic receptor

Identifiers

PMID42509834
PMCPMC13406445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.