Inflammation-Associated Transcriptional Remodeling of Antioxidant and Stress Signaling Pathways in First-Trimester Placenta in Maternal Overweight and Obesity.

Denise Hoch, Alejandro Majali-Martinez, Francisco Algaba Chueca, Silvija Tokic, Gernot Desoye

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Denise HochDepartment of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria.

Alejandro Majali-MartinezDepartment of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-9009-5810

Francisco Algaba ChuecaDepartment of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-6537-1502

Silvija TokicDepartment of Paediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria.

Gernot DesoyeDepartment of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-5715-3230

Funding

FWF Austrian Science Fund W1241Kulturamt der Stad GrazMedical University of GrazNational Bank of Austria 17950

6 · The paper itself

Abstract

The first trimester (FT) of pregnancy is characterized by rapid placental growth and differentiation, rendering this period sensitive to maternal metabolic influences. Maternal obesity is associated with chronic low-grade inflammation and altered redox homeostasis with implications in later cardiometabolic risk in offspring, yet its impact on early placental oxidative stress remains unclear. Here, we investigated whether maternal overweight and obesity are associated with oxidative lipid and protein damage and altered expression of antioxidant enzymes and stress signaling pathways. Placental tissue from lean (BMI < 25 kg/m

Indexed as

AntioxidantsInflammationObesityOverweightPlacentaPregnancy Trimester, FirstAdultFemaleHumansOxidative StressPregnancySignal TransductionAntioxidantsantioxidant enzymesfirst trimestermaternal overweight and obesityoxidative damageoxidative stressplacentastress signaling genes

Identifiers

PMID42509826

DOI10.3390/biom16071033

PMCPMC13406860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.