ArticleBiomolecules2026
Beyond Equilibrium Refractive-Index Shifts: Dynamical Information Encoded in Sensorgrams.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disordered Ag-nanowire localized surface plasmon resonance sensorgrams for glycated hemoglobin (HbA1c) detection exhibit reproducible multi-component temporal structures that cannot be fully explained within conventional equilibrium refractive-index models; in particular, the quantification of the molecular target escapes from the classical theory. The HbA1c-associated contribution emerges at earlier times while displaying slower relaxation dynamics compared with naïve hemoglobin-associated kinetics, revealing the coexistence of distinct activation and interfacial relaxation pathways. Analysis of temporal derivatives, phase-space trajectories, characteristic peak times, and relaxation times aims to suggest that the plasmonic response originates from multiple competing nonequilibrium processes evolving on different timescales. The description of the structured temporal response relies on a phenomenological framework incorporating activation and relaxation dynamics. Dynamical redistribution pathways associated with heterogeneous adsorption, hydration-shell relaxation, and plasmonic coupling within spatially non-uniform electromagnetic environments, along with resonance shift, support molecular fingerprint. The findings suggest that sensorgrams contain molecular information hidden beyond conventional equilibrium optical observables, motivating a transition toward dynamical and time-resolved approaches in plasmonic biosensing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.