ArticleBiomolecules2026
High Corticosterone Affects Somite Development During Early Avian Embryogenesis.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Maternal stress has been associated with altered embryonic and fetal development, yet the mechanisms by which stress hormones influence early developmental processes remain poorly understood. Early embryogenesis is particularly sensitive because it establishes the vertebrate body plan through tightly regulated events such as somitogenesis. Disruptions during this developmental window may therefore compromise normal morphogenesis and tissue organization. In the present study, we investigated whether elevated acute corticosterone exposure affects somite phenotype and Sonic hedgehog (SHH) signalling during early embryogenesis using the avian chick embryo model. Fertilized specific pathogen-free (SPF) chick eggs were incubated until Hamburger-Hamilton stage 12 (approximately 48 h of incubation) and subsequently injected with 15 µg corticosterone into the yolk sac to mimic acute high-stress conditions for 4 h. Macroscopic examination revealed increased inter-somitic distances between the first five visible pairs of somites in corticosterone-treated embryos compared with controls, suggesting altered somite organization. In addition, histological assessment indicated that corticosterone-treated embryos displayed occasional cells with morphological features consistent with cellular degeneration or cell death. Molecular analysis demonstrated significant downregulation of
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