Evidence map›Paper›PMID 42509806›Full record

ArticleBiomolecules2026

Reference Genes for Circadian Profiling of Core Clock Genes in the Blood of Obstructive Sleep Apnea Patients.

Katarina Nahtigal, Ana Halužan Vasle, Tinkara Kreft, Cene Skubic, Miha Mraz, Miha Moškon, Leja Dolenc Grošelj, Damjana Rozman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katarina NahtigalCentre for Functional Genomics and Bio-Chips, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-7796-1585
Ana Halužan VasleComputational Biology Group, Faculty of Computer and Information Science, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0001-5135-3752
Tinkara KreftCentre for Functional Genomics and Bio-Chips, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0009-0001-4735-2025
Cene SkubicCentre for Functional Genomics and Bio-Chips, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-2601-2291
Miha MrazComputational Biology Group, Faculty of Computer and Information Science, University of Ljubljana, 1000 Ljubljana, Slovenia.
Miha MoškonComputational Biology Group, Faculty of Computer and Information Science, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0003-4600-1730
Leja Dolenc GrošeljCentre for Functional Genomics and Bio-Chips, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0009-0009-4609-8318
Damjana RozmanCentre for Functional Genomics and Bio-Chips, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

Funding

ELIXIR Infrastructure ESFRI-ELIXIR GrantThe Slovenian Research and Innovation Agency J1-50024The Slovenian Research and Innovation Agency P1-0390The Slovenian Research and Innovation Agency P2-0359The Slovenian Research and Innovation Agency P3-0338The Slovenian Research and Innovation Agency Young Researcher GrantUniversity Clinical Centre Ljubljana Tertiary Project No. 20220001
6 · The paper itself

Abstract

Circadian rhythm disruptions are increasingly recognized in disorders such as obstructive sleep apnea (OSA), yet analysis of 24 h gene expression patterns remains challenging due to the lack of reliable reference genes for normalization. Even commonly used housekeeping genes may exhibit circadian oscillations, which can confound rhythmic gene expression analyses and hinder biomarker identification. To address this limitation, we evaluated the gene expression stability of 11 commonly used housekeeping genes in blood collected every 6 h over 24 h period from 40 adults with varying OSA severity and controls. Stability ranking by analytical tools RefFinder and EndoGeneAnalyzer identified

Indexed as

Circadian ClocksCircadian RhythmGene Expression ProfilingSleep Apnea, ObstructiveAdultFemaleHumansMaleMiddle AgedReference StandardsRibosomal ProteinsRibosomal Proteinscircadian rhythmscore clock genesgene expression stabilityobstructive sleep apneaqRT-PCR normalizationreference genes

Identifiers

PMID42509806
PMCPMC13406326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.