Evidence map›Paper›PMID 42509802›Full record

Observational studyBiomolecules2026

Effects of Cigarette Smoking on Oxidative Stress, DNA Damage, Immunological Profile, Viral Susceptibility, and Survival in Patients with Chronic Obstructive Pulmonary Disease.

Antonio de Iure, Laura Vitiello, Stefania Proietti, Paola Fortugno, Dolores Limongi, Carla Prezioso, Fabrizio Maggi, Guido Antonelli, Barbara Picconi, Carlo Tomino and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Antonio de IureDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.
Laura VitielloDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0003-0776-3601
Stefania ProiettiAgEA Coordinating Body, 00185 Rome, Italy.
Paola FortugnoDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0002-0151-6477
Dolores LimongiDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.
Carla PreziosoDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0002-8377-0742
Fabrizio MaggiNational Institute for Infectious Diseases "Lazzaro Spallanzani"-INMI IRCCS, Via Portuense 292, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Guido AntonelliDepartment of Molecular Medicine, Sapienza University, Viale Porta Tiburtina 28, 00185 Rome, Italy.ORCID 0000-0002-2533-2939
Barbara PicconiDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0001-6020-1021
Carlo TominoScientific Direction, IRCCS San Raffaele, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0003-1823-2195
Giorgio FelzaniSan Raffaele Sulmona, Viale dell'Agricoltura, 67039 Sulmona, Italy.
Stefano BonassiDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0003-3833-6717
Patrizia RussoDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.

Funding

Ministry of Universities and Research B53D23003760006/G53D23000700001
6 · The paper itself

Abstract

backgroundCigarette smoking promotes persistent systemic alterations in COPD, yet the interplay among genetic susceptibility, oxidative stress, immune dysregulation, impaired control of persistent viral replication, and long-term outcomes remains incompletely understood.

methodsWe conducted an observational study in 102 patients aged ≥70 years with severe-to-very-severe COPD undergoing pulmonary rehabilitation. Current smokers (n = 38) were compared with never/former smokers (n = 64). Analyses included Chr15q25 genotyping (rs16969968), oxidative stress biomarkers (tail intensity, 8-OHdG, MDA, and bilirubin), hematological and immunological parameters, α7nAChR expression, TTV load as a surrogate marker of immune competence, latent virus prevalence, and five-year survival assessed by multivariable Cox regression.

resultsCurrent smokers exhibited significantly higher DNA damage (tail intensity,

conclusionsIn severe-to-very-severe COPD, smoking is associated with a distinct biological profile characterized by enhanced oxidative DNA damage, systemic inflammation, immune remodeling, reduced antioxidant defenses, and impaired control of persistent viral replication. WBC and bilirubin emerged as the biomarkers most consistently associated with long-term outcomes. These findings support integrated biological profiling as a tool for risk stratification and precision-guided rehabilitation in advanced COPD.

Indexed as

Cigarette SmokingDNA DamageOxidative StressPulmonary Disease, Chronic ObstructiveAgedBiomarkersFemaleHumansMaleBiomarkerschronic obstructive pulmonary diseasecigarette smokingDNA damageimmune dysregulationnicotinic receptorsoxidative stressprecision medicinepulmonary rehabilitationsurvivalTorque teno virus

Identifiers

PMID42509802
PMCPMC13406268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.