Evidence map›Paper›PMID 42509799›Full record

ReviewBiomolecules2026

GPX4 in the Tumor Microenvironment: Not Just Inhibiting Ferroptosis, but Immuno-Metabolic Regulation.

Xinzhe Li, Manxuan Zhang, Zenan Xu, Reziyamu Wufuer, Wenfang Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinzhe LiSchool of Pharmacy & Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.
Manxuan ZhangSchool of Pharmacy & Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.
Zenan XuSchool of Pharmacy & Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.ORCID 0009-0001-4806-8261
Reziyamu WufuerSchool of Pharmacy & Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.
Wenfang LiSchool of Pharmacy & Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.ORCID 0000-0003-0436-4277

Funding

the Natural Science Foundation of Xinjiang Uygur Autonomous Region 2024D01C58the Natural Science Foundation of Xinjiang Uygur Autonomous Region 2025D01C56the Undergraduate Innovation Training Program of Xinjiang University 202510755105
6 · The paper itself

Abstract

Glutathione peroxidase 4 (GPX4) is canonically viewed as the primary suppressor of ferroptosis, yet its role in the tumor microenvironment (TME) extends far beyond antioxidant catalysis to encompass immuno-metabolic regulation. In this review, we synthesize recent advances in enzymology, immunology, and cancer metabolism to propose a "lipid peroxidation threshold" framework, wherein GPX4 sets cell-type-specific thresholds that determine susceptibility to ferroptosis across tumor cells, CD8

Indexed as

FerroptosisNeoplasmsPhospholipid Hydroperoxide Glutathione PeroxidaseTumor MicroenvironmentAnimalsHumansLipid PeroxidationPhospholipid Hydroperoxide Glutathione Peroxidasecancer immunotherapyferroptosisGPX4immuno-metabolic checkpointlipid peroxidation thresholdspatial heterogeneitytherapeutic resistancetumor microenvironment

Identifiers

PMID42509799
PMCPMC13406432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.