Evidence map›Paper›PMID 42509782›Full record

ArticleBiomolecules2026

Reduced Synaptophysin-like 2 (MG29/SYPL2) Levels Mimic Age-Related Alterations in Skeletal Muscle Calcium Homeostasis and Lipid Signaling.

Kamal Awad, Jian Huang, Marian N Aziz, Zhiying Wang, Leticia Brotto, Kyung Eun Lee, Jongsoo Kim, Rajendiran Karthikraj, Liubov V Gushchina, Noah Weisleder and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kamal AwadBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0003-3621-1136
Jian HuangBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Marian N AzizMolecular Imaging Program, Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Zhiying WangBristol Myers Squibb, Princeton, NJ 08540, USA.
Leticia BrottoBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Kyung Eun LeeDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Jongsoo KimDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Rajendiran KarthikrajBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Liubov V GushchinaJerry R. Mendell Center for Gene Therapy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-5639-442X
Noah WeislederDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Marco BrottoBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.

Funding

UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
Regulation of Store-Operated Calcium Entry During Muscle AgingR01AG056504 · NIA · OHIO STATE UNIVERSITY · PI BROTTO, MARCO, WEISLEDER, NOAH · 2018 to 2022
$2.6M
MG29 function in regulation of Store-Operated Calcium Entry during Muscle AgingR56AG049083 · NIA · OHIO STATE UNIVERSITY · PI BROTTO, MARCO, WEISLEDER, NOAH · 2015 to 2015
$310k
NCATS NIH HHS UL1 TR003163NIA NIH HHS P01 AG039355NIA NIH HHS R01 AG056504NIA NIH HHS R56 AG049083NIH HHS 1R56AG049083-01NIH HHS 1UL1TR003163-04NIH HHS 5P01AG039355-12NIH HHS 5R01AG056504-02Trauma Research and Combat Casualty Care Collaborative (TRC4) by the UT System TRC4-2024--0000000031
6 · The paper itself

Abstract

Sarcopenia is characterized by progressive loss of skeletal muscle mass and function and is a major contributor to frailty, disability, and mortality in older adults. Store-operated calcium entry (SOCE) is a crucial regulator of skeletal muscle calcium homeostasis, and impaired SOCE has been linked to age-related muscle weakness. Here, we identify the synaptophysin family member synaptophysin-like protein 2, also known as mitsugumin 29 (MG29; encoded by the human gene

Indexed as

AgingCalciumMuscle, SkeletalAnimalsCalcium SignalingCholesterolHomeostasisHumansLipid MetabolismMiceMice, KnockoutMuscle Fibers, SkeletalSarcopeniaSignal TransductionCalciumCholesterolcalcium homeostasislipid signalingMG29mitsugumin 29sarcopeniaskeletal muscleSOCE

Identifiers

PMID42509782
PMCPMC13406257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.